[Investigation on distribution of HBV genotype and serotype from Tibetan in Tongde, Qinghai] Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi] Journal article | | Title | [Investigation on distribution of HBV genotype and serotype from Tibetan in Tongde, Qinghai] | | Author(s) | Zang J, Jiang SY, Wang XW, Wang F, Bian T, Mu ZY, Zhang Y | | Institution | Department of Epidemiology and Healthy Statistics, Hebei Medical University, Shijiazhuang 050017, China. | | Source | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2009 Feb; 23(1):2-4. | | Abstract | OBJECTIVE: To explore the distribution of HBV genotype and serotype from Tibetan in Tongde, Qinghai.
METHODS: Nested polymerase chain reaction (nPCR) was used for amplification of S gene and C gene of HBV from sera carried by Tibetan chronic HBV carrier in Tongde, Qinghai, then the HBV DNA positive products were sequenced by direct sequencing. Genotype and serotype were identified by analysis of sequence result.
RESULTS: 271, which come from 311 sera samples with positive HBsAg randomly selected from natural community, were amplified and sequenced in both S gene and C gene successfully, 10 (3.7%), 261 (96.3%) out of them were identified as genotype C, recombinant between genotypes C and D respectively; 259 (95.6%), 10 (3.7%), 2 (0.7%) belonged to serotype ayw2, adr, adw2 respectively.
CONCLUSION: The recombinant between genotypes C and D was the main genotype in Tibetan chronic carrier with hepatitis Bin Tongde, Qinghai; the serotype of this areas was consisted largely of ayw2. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19799002 |
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